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There is also some research that shows they're useful for problems in other parts of your body. For example, some people say they have helped with:
Your healthcare provider might suggest using these products preventively if you have a history of infections, or using them to help restore your microbiome after treatment with antibiotics. Caldovic, L. & Tuchman, M. N-acetylglutamate and its changing role through evolution. Biochem. J. 372, 279–290 (2003). A general recommendation is to choose probiotic products with at least 1 billion colony-forming units and containing the genus Lactobacillus, Bifidobacterium, Bacillusor Saccharomyces boulardii, some of the most researched probiotics. Even then, you may have to delve deeper, as each genus of bacteria encompasses numerous strains that produce different results.
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Reduces tiredness and fatigue, supports normal muscle & heart function & normal function of the immune system.
Ibrahim, A. et al. Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease: a randomised controlled trial. PLos ONE 15, 17 (2020). Kraken2 tool and NCBI nonredundant Nucleotide Sequence Database were used to annotate the MAG contigs with default parameters 85. Prodigal was used to predict putative genes in the contigs 86. Then the predicted genes were searched against the UniProt Knowledgebase using the blastp function of DIAMON. Boehme, M. et al. Microbiota from young mice counteracts selective age-associated behavioral deficits. Food Behav. Res. 1, 666–67 (2021).Department of Neurology, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, 264200, China Probiotics are sold as supplements, which means they’re not regulated by the U.S. Food and Drug Administration (FDA). This means companies can essentially throw whatever they want into a supplement and call it a probiotic. To keep yourself safe and make sure you’re getting the probiotics you really want, you’ll need to keep a keen eye on the labeling and read up on scientific studies and research reports to determine which probiotics have made positive outcomes on specific conditions. Feng, W., Ao, H. & Peng, C. Gut microbiota, short-chain fatty acids, and herbal medicines. Front. Pharmacol. 9, 1354 (2018). The gut microbiota of patients with PD was reported to have reduced carbohydrate fermentation and butyrate synthesis capacity and increased proteolytic fermentation compared with healthy individuals 6. Some taxa in the phylum Firmicutes, such as Butyricimonas and Clostridiam clusters IV and XIV, have been considered as protagonists of carbohydrate fermentation and butyrate production 48, 49. Our study found that some SGBs in Firmicutes ( Butyricimonas sp. CAG:1, Lachnospira eligens, Clostridiales sp. CAG:26, etc.) increased after probiotic intake. Moreover, SGBs involved in SCFAs (butyrate, isovaleric acid, and propionate) synthesis increased in the Probio-M8 group after intervention. Bacteroides were reported to be GABA-producers, and their relative abundance correlated negatively with the brain signatures associated with depression 15. Interestingly, our data showed that more GABA synthesis modules-encoding SGBs were identified in the probiotic group; and more Bacteroides intestinalis was found in the Probio-M8 group, which was associated with increased MMSE scores as well. Our data also showed that more SGBs representing Prevotella and Lactobacillus were found in the placebo group after the course of intervention. Prevotella were found to increase in patients with PD, and they played important roles in the metabolism of mucus layer glycoprotein, the permeability of the intestinal barrier, and inflammation 50, 51. Some Lactobacillus could produce specific enzymes that convert levodopa into dopamine before it reaches the brain, thus decreasing the drug efficacy and increasing the required dose for clinical effectiveness 13, 52. Our results showed that the abundance of L. fermentum in the placebo group was significantly associated with a less fit mental state (characterized by higher scores of HAMA and HAMD; lower scores of MMSE) and more serious illness (characterized by higher scores of UPDRS). In addition, some neuroinflammation-associated pathogens decreased after Probio-M8 intervention, such as P. distasonis, Evtepia gabavorous, and, K. oxytoca. The species, P. distasonis, correlated negatively with hippocampal function, while K. oxytoca could induce anxiety and colitis, and the population of apoptotic neuron cells in the brain of mice via production of lipopolysaccharide and enterotoxins 53, 54, 55. In our study, K. oxytoca was found to be significantly and negatively associated with feces hardness in patients with PD. Therefore, it was likely that the clinical remissive effect of Probio-M8 was related to the regulation of specific gut microbiota in patients with PD. The first capsule in Probio7 50 PLUS provides 10 billion friendly bacteria from 8 strains, plus 1 billion S. boulardii, a strain of friendly yeast. It also contains 2 types of natural fibre which feed and encourage friendly bacteria in your digestive system. The second capsule contains carefully selected vitamins and minerals, plant extracts (ginkgo biloba and curcuma) and fish oils to help you maintain a healthy mind and body.
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